Comparison of the clinical characteristics and outcomes of Klebsiella pneumoniae and Streptococcus pneumoniae meningitis.

Diagn Microbiol Infect Dis. 2015 Feb 20. pii: S0732-8893(15)00040-1. doi: 10.1016/j.diagmicrobio.2015.02.006. [Epub ahead of print]

Comparison of the clinical characteristics and outcomes of Klebsiella pneumoniae and Streptococcus pneumoniae meningitis.

Jung J1, Park KH2, Park SY3, Song EH4, Lee EJ5, Choi SH6, Choo EJ7, Kwak YG8, Sung H9, Kim SH1, Lee SO1, Kim MN9, Kim YS1, Woo JH1, Choi SH10.

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Abstract

This multicenter, retrospective cohort study compared the clinical characteristics and outcomes of community-acquired Klebsiella pneumoniae meningitis (CA-KPM) with those of community-acquired Streptococcus pneumoniae meningitis (CA-SPM). Eighty-three adult patients, 27 with CA-KPM and 56 with CA-SPM, were included. Diabetes mellitus (48.1% versus 21.4%; P=0.01) and liver cirrhosis (22.2% versus 5.4%; P=0.05) were more commonly associated with CA-KPM. Comatose mental status (40.7% versus 12.5%; P=0.01), septic shock (44.4% versus 8.9%; P<0.001), and concomitant extrameningeal infections (40.7% versus 7.1%; P=0.001) were also more common in the CA-KPM group. The 28-day mortality (44.4% versus 10.7%; P<0.001) and inhospital mortality (51.9% versus 14.3%; P<0.001) were higher in the CA-KPM group. In conclusion, diabetes mellitus and liver cirrhosis are more common in the CA-KPM patients who were also more likely to present with severe manifestations and poor outcomes.

Copyright © 2015. Published by Elsevier Inc.

KEYWORDS:

Klebsiella pneumoniae; Meningitis; Streptococcus pneumoniae

PMID: 25752203 [PubMed - as supplied by publisher]