Int J Gen Med. 2014 May 21;7:253-7. doi: 10.2147/IJGM.S63744. eCollection 2014.
Community-acquired pneumonia caused by carbapenem-resistant Streptococcus pneumoniae: re-examining its prevention and treatment.
Doi A1, Iwata K2, Takegawa H3, Miki K4, Sono Y1, Nishioka H5, Takeshita J6, Tomii K7, Haruta T8.
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Abstract
A 73-year-old man with no significant past medical history or any history of health care visits was hospitalized for pneumonia. Sputum culture revealed multidrug-resistant Streptococcus pneumoniae, even to carbapenems. The patient was later treated successfully with levofloxacin. Throat cultures from his two grandchildren revealed S. pneumoniae with the same susceptibility pattern. Analysis for resistant genes revealed gPRSP (pbp1a + pbp2x + pbp2b gene variants) in both the patient and his grandchildren, none of whom had received pneumococcal vaccines of any kind. This case illustrates the importance of the emergence of carbapenem-resistant S. pneumoniae. Non-rational use of carbapenems for community-acquired infections may be counterproductive. This case also highlights the importance of pneumococcal vaccinations in children and the elderly.
KEYWORDS:
Streptococcus pneumoniae; carbapenem resistance; pneumonia
PMID: 24899822 [PubMed] PMCID: PMC4038523 Free PMC Article
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