PLoS Pathog. 2015 Jul 16;11(7):e1005034. doi: 10.1371/journal.ppat.1005034. eCollection 2015.
Vaccination Drives Changes in Metabolic and Virulence Profiles of Streptococcus pneumoniae.
Watkins ER1, Penman BS1, Lourenço J1, Buckee CO2, Maiden MC1, Gupta S1.
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Abstract
The bacterial pathogen, Streptococcus pneumoniae (the pneumococcus), is a leading cause of life-threatening illness and death worldwide. Available conjugate vaccines target only a small subset (up to 13) of >90 known capsular serotypes of S. pneumoniae and, since their introduction, increases in non-vaccine serotypes have been recorded in several countries: a phenomenon termed Vaccine Induced Serotype Replacement (VISR). Here, using a combination of mathematical modelling and whole genome analysis, we show that targeting particular serotypes through vaccination can also cause their metabolic and virulence-associated components to transfer through recombination to non-vaccine serotypes: a phenomenon we term Vaccine-Induced Metabolic Shift (VIMS). Our results provide a novel explanation for changes observed in the population structure of the pneumococcus following vaccination, and have important implications for strain-targeted vaccination in a range of infectious disease systems.
PMID: 26181911 [PubMed - in process] PMCID: PMC4504489
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