Antimicrobial Susceptibility/Resistance of Streptococcus Pneumoniae.

Mater Sociomed. 2015 Jun;27(3):180-4. doi: 10.5455/msm.2015.27.180-184. Epub 2015 Jun 8.

Antimicrobial Susceptibility/Resistance of Streptococcus Pneumoniae.

Karcic E1, Aljicevic M2, Bektas S3, Karcic B4.

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Abstract

INTRODUCTION:

Pneumococcal infections are a major cause of morbidity and mortality worldwide, whose treatment is threatened with an increase in the number of strains resistant to antibiotic therapy.

GOAL:

The main goal of this research was to investigate the presence of antimicrobial susceptibility/resistance of S. pneumoniae.

MATERIAL AND METHODS:

Taken are swabs of the nose and nasopharynx, eye and ear. In vitro tests that were made in order to study the antimicrobial resistance of pneumococci are: disk diffusion method and E-test.

RESULTS:

The resistance to inhibitors of cell wall synthesis was recorded at 39.17%, protein synthesis inhibitors 19.67%, folate antagonists 47.78% and quinolone in 1.11%. S. pneumoniae has shown drug resistance to erythromycin in 45%, clindamycin in 45%, chloramphenicol-0.56%, rifampicin-6.11%, tetracycline-4.67%, penicillin-G in 4.44%, oxacillin in 73.89%, ciprofloxacin in 1.11% and trimethoprim-sulfamethoxazole in 5.34% of cases.

CONCLUSION:

The highest resistance pneumococcus showed to erythromycin, clindamycin and trimethoprim-sulfamethoxazole and these should be avoided in the treatment. The least resistance pneumococcus showed to tetracycline, rifampicin, chloramphenicol, penicillin-G and ciprofloxacin.

KEYWORDS:

antibiotics; pneumococcus; resistance; susceptibility

PMID: 26236165 [PubMed]