Effects of Immunomodulators on Functional Activity of Innate Immunity Cells Infected with Streptococcus pneumoniae.

Bull Exp Biol Med. 2015 Feb 24. [Epub ahead of print]

Effects of Immunomodulators on Functional Activity of Innate Immunity Cells Infected with Streptococcus pneumoniae.

Plekhova NG1, Kondrashova NM, Somova LM, Drobot EI, Lyapun IN.

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Abstract

Low activity of bactericidal enzymes was found in innate immunity cells infected with S. pneumonia. The death of these cells was fastened under these conditions. On the contrary, treatment with antibiotic maxifloxacin was followed by an increase in activity of bactericidal enzymes in phagocytes and induced their death via necrosis. Analysis of the therapeutic properties of immunomodulators tinrostim and licopid in combination with maxifloxacin showed that these combinations correct functional activity of cells infected with S. pneumonia.

PMID: 25708326 [PubMed - as supplied by publisher]